ANTI-TOXIC PRINCIPLES FROM MORINGA OLEIFERA AND MUSA SAPIENTIUM DOWN-REGULATED KI67 AND MULTIDRUG RESISTANCE1 PROTEINS IN CADMIUM CHLORIDE-INDUCED HEPATO-TOXICITY AND MUTAGENESIS IN RATS

Adelaja Akinlolu; Risikat Kadir; Adeoye Oyewopo; Mubarak Ameen; Emmanuel Okorie; Joshua Jolaiya; Stacey Olawale; Mercy Alawode; Oluwatosin Omiyale

doi:10.31838/ijprt/12.01.07

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IJPRT. 2022; 12(1): 67-74

doi: 10.31838/ijprt/12.01.07

ANTI-TOXIC PRINCIPLES FROM MORINGA OLEIFERA AND MUSA SAPIENTIUM DOWN-REGULATED KI67 AND MULTIDRUG RESISTANCE1 PROTEINS IN CADMIUM CHLORIDE-INDUCED HEPATO-TOXICITY AND MUTAGENESIS IN RATS

Adelaja Akinlolu, Risikat Kadir, Adeoye Oyewopo, Mubarak Ameen, Emmanuel Okorie, Joshua Jolaiya, Stacey Olawale, Mercy Alawode, Oluwatosin Omiyale.

Abstract
Moringa oleifera (MO) and Musa sapientium (MS) are ethno-medicinal plants with anticancer potentials. Cadmium is a pro-carcinogen of global health concerns. This study evaluated the anticancer potentials of MOF6 (extracted from MO leaves) and MSF1 (extracted from MS suckers) on immuno-modulations of Ki67 (proliferation biomarker) and Multi-drug resistance1 (MDR1) proteins in the liver of rats in Cadmium Chloride (CdCl)-induced hepato-toxicity and mutagenesis. 55 adult male rats were randomly divided into 11 groups (n = 5). Group 1 received physiological saline. Groups 2-6 and 10-11 received single intra-peritoneal administration of 1.25mg/kg bodyweight of CdCl on Day 1. Groups 3-5 were treated with 15 and 30mg/kg bodyweight of MOF6, and 10mg/kg bodyweight of MSF1 respectively from Days 15-56. Group 6 was treated with 3.35 mg/kg bodyweight of Doxorubicin and intravenous injection of 0.5ml/200g of Cisplatin from Days 15-29. Groups 7-9 received only 15 and 30mg/kg bodyweight of MOF6, and 10mg/kg bodyweight of MSF1 respectively from Days 1-56. Groups 10 and 11 received preventive treatments with 30mg/kg bodyweight of MOF6 and 10mg/kg bodyweight of MSF1 respectively from Days 1-56. Doxorubicin and extracts doses were administered orally. Consequently, Ki67 and MDR1 concentrations in Liver homogenates were evaluated using Enzyme Linked Immunosorbent Assay. Computed data were statistically analyzed (pâ‰¤0.05). Results showed statistically significant (pâ‰¤0.05) and non-significant decreased concentrations (pâ‰¥0.05) of Ki67 and MDR1 in Groups 3-11 compared with Group 2. Therefore, MOF6 and MSF1 ameliorated CdCl-induced hepato-toxicity, mutagenesis, hyperplasia and drug resistance. In conclusion, MOF6 and MSF1 possess hepato-protective, anti-proliferation, anti-drug resistance and anticancer potentials.

Key words: Moringa oleifera, Musa sapientum, Cadmium Chloride, Anti-cancer compound, Ki67, Multidrug resistance1

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Pubmed Style

Akinlolu A, Kadir R, Oyewopo A, Ameen M, Okorie E, Jolaiya J, Olawale S, Alawode M, Omiyale O. ANTI-TOXIC PRINCIPLES FROM MORINGA OLEIFERA AND MUSA SAPIENTIUM DOWN-REGULATED KI67 AND MULTIDRUG RESISTANCE1 PROTEINS IN CADMIUM CHLORIDE-INDUCED HEPATO-TOXICITY AND MUTAGENESIS IN RATS. IJPRT. 2022; 12(1): 67-74. doi:10.31838/ijprt/12.01.07

Web Style

Akinlolu A, Kadir R, Oyewopo A, Ameen M, Okorie E, Jolaiya J, Olawale S, Alawode M, Omiyale O. ANTI-TOXIC PRINCIPLES FROM MORINGA OLEIFERA AND MUSA SAPIENTIUM DOWN-REGULATED KI67 AND MULTIDRUG RESISTANCE1 PROTEINS IN CADMIUM CHLORIDE-INDUCED HEPATO-TOXICITY AND MUTAGENESIS IN RATS. https://www.ijprt.org/?mno=115694 [Access: April 05, 2022]. doi:10.31838/ijprt/12.01.07

AMA (American Medical Association) Style

Akinlolu A, Kadir R, Oyewopo A, Ameen M, Okorie E, Jolaiya J, Olawale S, Alawode M, Omiyale O. ANTI-TOXIC PRINCIPLES FROM MORINGA OLEIFERA AND MUSA SAPIENTIUM DOWN-REGULATED KI67 AND MULTIDRUG RESISTANCE1 PROTEINS IN CADMIUM CHLORIDE-INDUCED HEPATO-TOXICITY AND MUTAGENESIS IN RATS. IJPRT. 2022; 12(1): 67-74. doi:10.31838/ijprt/12.01.07

Vancouver/ICMJE Style

Akinlolu A, Kadir R, Oyewopo A, Ameen M, Okorie E, Jolaiya J, Olawale S, Alawode M, Omiyale O. ANTI-TOXIC PRINCIPLES FROM MORINGA OLEIFERA AND MUSA SAPIENTIUM DOWN-REGULATED KI67 AND MULTIDRUG RESISTANCE1 PROTEINS IN CADMIUM CHLORIDE-INDUCED HEPATO-TOXICITY AND MUTAGENESIS IN RATS. IJPRT. (2022), [cited April 05, 2022]; 12(1): 67-74. doi:10.31838/ijprt/12.01.07

Harvard Style

Akinlolu, A., Kadir, . R., Oyewopo, . A., Ameen, . M., Okorie, . E., Jolaiya, . J., Olawale, . S., Alawode, . M. & Omiyale, . O. (2022) ANTI-TOXIC PRINCIPLES FROM MORINGA OLEIFERA AND MUSA SAPIENTIUM DOWN-REGULATED KI67 AND MULTIDRUG RESISTANCE1 PROTEINS IN CADMIUM CHLORIDE-INDUCED HEPATO-TOXICITY AND MUTAGENESIS IN RATS. IJPRT, 12 (1), 67-74. doi:10.31838/ijprt/12.01.07

Turabian Style

Akinlolu, Adelaja, Risikat Kadir, Adeoye Oyewopo, Mubarak Ameen, Emmanuel Okorie, Joshua Jolaiya, Stacey Olawale, Mercy Alawode, and Oluwatosin Omiyale. 2022. ANTI-TOXIC PRINCIPLES FROM MORINGA OLEIFERA AND MUSA SAPIENTIUM DOWN-REGULATED KI67 AND MULTIDRUG RESISTANCE1 PROTEINS IN CADMIUM CHLORIDE-INDUCED HEPATO-TOXICITY AND MUTAGENESIS IN RATS. International Journal of Pharmacy Research & Technology, 12 (1), 67-74. doi:10.31838/ijprt/12.01.07

Chicago Style

Akinlolu, Adelaja, Risikat Kadir, Adeoye Oyewopo, Mubarak Ameen, Emmanuel Okorie, Joshua Jolaiya, Stacey Olawale, Mercy Alawode, and Oluwatosin Omiyale. "ANTI-TOXIC PRINCIPLES FROM MORINGA OLEIFERA AND MUSA SAPIENTIUM DOWN-REGULATED KI67 AND MULTIDRUG RESISTANCE1 PROTEINS IN CADMIUM CHLORIDE-INDUCED HEPATO-TOXICITY AND MUTAGENESIS IN RATS." International Journal of Pharmacy Research & Technology 12 (2022), 67-74. doi:10.31838/ijprt/12.01.07

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

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