E-ISSN 2250-0944 | ISSN 2250-1150
 

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FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE

ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL..

Abstract
The aim of the present study was to formulate and develop Nanoparticulate drug delivery system (Nanostructured Lipid Carrier) for the treatment of Acne. The nanostructured lipid carrier was prepared by high speed and high pressure homogenizer by using different types of solid lipid, liquid lipid and concentration of surfactants. The NLC was characterized by particle size, zeta potential, polydispersity index. Stearic acid and oleic acid were used as solid lipid and liquid lipid and Pluronic F-68 was used as surfactant. The drug excipient compatibility study was performed by Fourier transform infrared spectrophotometer and the result revealed that all the excipients and drugs were compatible with each other. For the drug estimation HPLC method was developed for the combined drug Clindamycin phosphate and Nicotinamide. Formulation of nanoemulsion was prepared by high speed and high pressure homogenization technique. This emulsion was incorporated into the gel which was prepared by using Carbopol 934P as gel base and evaluated for the In-vitro release. Factorial design was used for the evaluation and optimization of the nanoparticles. Short term stability study was performed for 30 days and there was no significant change in consistency, pH and viscosity

Key words: NLC (Nanostructured Lipid Carriers), High pressure homogenizer, Clindamycin Phosphate, Nicotinamide


 
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Pubmed Style

ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.. FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE. IJPRT. 2018; 8(2): 14-26. doi:10.31838/ijprt/08.02.02


Web Style

ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.. FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE. https://www.ijprt.org/?mno=302643734 [Access: June 25, 2022]. doi:10.31838/ijprt/08.02.02


AMA (American Medical Association) Style

ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.. FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE. IJPRT. 2018; 8(2): 14-26. doi:10.31838/ijprt/08.02.02



Vancouver/ICMJE Style

ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.. FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE. IJPRT. (2018), [cited June 25, 2022]; 8(2): 14-26. doi:10.31838/ijprt/08.02.02



Harvard Style

ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL. (2018) FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE. IJPRT, 8 (2), 14-26. doi:10.31838/ijprt/08.02.02



Turabian Style

ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.. 2018. FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE. International Journal of Pharmacy Research & Technology, 8 (2), 14-26. doi:10.31838/ijprt/08.02.02



Chicago Style

ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.. "FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE." International Journal of Pharmacy Research & Technology 8 (2018), 14-26. doi:10.31838/ijprt/08.02.02



MLA (The Modern Language Association) Style

ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL.. "FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE." International Journal of Pharmacy Research & Technology 8.2 (2018), 14-26. Print. doi:10.31838/ijprt/08.02.02



APA (American Psychological Association) Style

ISHRAT S. CHHOWALA, DEVARSHI MADHUBHAI JANI, DR ABHAY DHARAMSI, DR. GAJANAN SHINDHE, DR. RAKESH PATEL. (2018) FORMULATION AND EVALUATION OF NANO PARTICULATE DRUG DELIVERY SYSTEM FOR AN EFFECTIVE TREATMENT OF ACNE. International Journal of Pharmacy Research & Technology, 8 (2), 14-26. doi:10.31838/ijprt/08.02.02





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