Evaluation of Urinary Biomarkers for Early Detection of Upper Tract  Urothelial Carcinoma: A Prospective Study

Zeeshan Shaukat, Ali Saqlain Haider, Muhammad Haroon Ghous, Muhammad Nadeem Shafique, Muhammad Adnan Sadiq, Nadeem Abbas

Evaluation of Urinary Biomarkers for Early Detection of Upper Tract Urothelial Carcinoma: A Prospective Study

Authors

Zeeshan Shaukat, Ali Saqlain Haider, Muhammad Haroon Ghous, Muhammad Nadeem Shafique, Muhammad Adnan Sadiq, Nadeem Abbas

Keywords:

Upper tract urothelial carcinoma, urinary biomarkers, early detection

Abstract

Upper tract urothelial carcinoma (UTUC) is often diagnosed at advanced stages due to limitationsof imaging and cytology. The present prospective study investigated the diagnostic performanceof selected urinary biomarkers in detecting early-stage UTUC. The primary objective was toevaluate sensitivity, specificity

References

Margel D, et al. NMP22 urinary biomarker accuracy in upper tract urothelial carcinoma detection. J Urol. https://doi.org/10.1097/JU.0000000000001702

;205(4):1234–1241. DOI:

Rayala S, et al. Bladder tumor antigen (BTA) test in UTUC: prospective validation. Int Urol Nephrol. 2021;53(11):2325–2332. DOI: https://doi.org/10.1007/s11255-021-028678

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Published

2025-09-23

How to Cite

Zeeshan Shaukat, Ali Saqlain Haider, Muhammad Haroon Ghous, Muhammad Nadeem Shafique, Muhammad Adnan Sadiq, Nadeem Abbas. (2025). Evaluation of Urinary Biomarkers for Early Detection of Upper Tract Urothelial Carcinoma: A Prospective Study. International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 2174–2180. Retrieved from https://ijprt.org/index.php/pub/article/view/1028