Influence of Anesthesia on Vancomycin Pharmacokinetics and  Pharmacodynamics in Septic ICU Patients with Augmented Renal Clearance:  Correlation with Serum Creatinine, Cystatin C, and Inflammatory Markers

Aun Muhammad, Abdul Waheed, Kiran Fatima, Shazia Hameed, Usman Zeeshan, Asia Firdous, Jarin Tasnim

Influence of Anesthesia on Vancomycin Pharmacokinetics and Pharmacodynamics in Septic ICU Patients with Augmented Renal Clearance: Correlation with Serum Creatinine, Cystatin C, and Inflammatory Markers

Authors

Aun Muhammad, Abdul Waheed, Kiran Fatima, Shazia Hameed, Usman Zeeshan, Asia Firdous, Jarin Tasnim

Keywords:

vancomycin pharmacokinetics, augmented renal clearance, cystatin C

Abstract

Sepsis-associated augmented renal clearance (ARC) substantially alters antimicrobialpharmacokinetics, yet the influence of anaesthesia on vancomycin disposition in such patientsremains underexplored. This prospective experimental study investigated the impact of anesthetic exposure on vancomycin

References

Luo Y, Ji S, Jiang M, Zhou B. Augmented renal clearance: What have we known and where are we going? Front Pharmacol. 2021;12:723731

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Published

2025-11-05

How to Cite

Aun Muhammad, Abdul Waheed, Kiran Fatima, Shazia Hameed, Usman Zeeshan, Asia Firdous, Jarin Tasnim. (2025). Influence of Anesthesia on Vancomycin Pharmacokinetics and Pharmacodynamics in Septic ICU Patients with Augmented Renal Clearance: Correlation with Serum Creatinine, Cystatin C, and Inflammatory Markers . International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 3082–3089. Retrieved from https://ijprt.org/index.php/pub/article/view/1164