Transdermal Drug Delivery Technology – A Prospective Review

Abstract

Transdermal drug delivery system (TDDS) has turn out to be a grand field for discovery and patents in drug delivery technology. The innovations in delivering the drug to systemic circulation by overcoming the hurdles related to API Characteristics like molecular size, lipophilicity, permeability, through physical or chemical enhancers is being achieved by using this drug delivery platform. More than 100 different kind of transdermal patch medications are available in market for various treatments, having more than 5 billon dollar worth sales. This mainly includes the class of drugs such as narcotics, analgesics, anti-anginal and contraceptives. Comparative study on risk factor on various dosage form shows transdermal drug delivery has less risk than other dosage forms and self-administration is possible, hence the patient compliance is higher for this dosage form. The patent application and literature search show the development of transdermal drug delivery in pharmaceutical field as remarkable area of research. Carrier mediated delivery is most recent advancement in this dosage form this includes liposomes, niosomes, proniosomes etc. This review presents basic sciences involved in Transdermal drug delivery system developments, market, literature, recent patents for transdermal formulation composition & system design & search from (USPTO), risk evaluation it also focus on current technologies future developments, manufacturing consideration, safety evaluation & Regulatory overview.