An Observational Study of Nerve Conduction Abnormalities in Patients of Chronic Kidney Disease Attending a Tertiary Care Centre

Abstract

Relevance: Metabolic neuropathy includes a wide spectrum of peripheral nerve disorders associated with systemic diseases of metabolic origin. These diseases include diabetes mellitus, uraemia, hypothyroidism, hepatic failure, hypoglycaemia, polycythaemia, amyloidosis, and porphyria, disorders of lipid/glycolipid metabolism, nutritional /vitamin deficiencies, and mitochondrial disorders. Diabetic mellitus is the most common cause of metabolic neuropathy, followed by uraemia.

Aims & objectives: To study the prevalence and patterns of Peripheral Neuropathy in patients with chronic kidney disease on maintenance Haemodialysis

Materials & Methods: This Study of Nerve Conduction Abnormalities in Metabolic Disorders, a cross sectional study was conducted in Narayana Medical College & Hospital between 1st April 2025 and 31st July 2025. Uremic patients were collected from department of nephrology who have come with neuropathy symptoms.

Results: Out of the 50 patients with CRF polyneuropathy was evident in 39(78%). Of these 21(42%) had clinical symptoms suggestive of polyneuropathy and 10(20%) patients had only objective evidence of neuropathy without symptoms of polyneuropathy and 8 (16%) patients had only electro physiological evidence.

Conclusions: The prevalence of polyneuropathy in CRF patients is Eighty percent out of which 25% were asymptomatic. Axonopathic changes were predominantly seen in affected patients. among nerves involved Sural SNAP and peroneal CMAP amplitudes were more sensitive parameters for detection of PN.