Comparative Study of Assay between Stanndared Paracetamol and Any Markated Product

Abstract

Background: Paracetamol (acetaminophen) is an acetanilide derivative with the molecular formula C8H9NO2. It is one of the most commonly used drugs worldwide; Paracetamol has analgesic and antipyretic but not anti-inflamatory activity. Paracetamol is a widely used non-prescription medication and is available in several brands in the market which makes it difficult to select the safe and effective one. Purpose: The study aims to establish the pharmaceutical equivalence between the branded paracetamol & standard paracetamol tablets and to justify the quality of branded paracetamol & standard paracetamol tablets Methodology: The study involves the quantitative analysis of twenty Paracetamol 500 mg tablets, using Ultra Violet Spectrophotometric methods, in which the samples were dissolved in 0.1M sodium hydroxide solution and distilled water and their various absorbances determined at the wavelength (λmax) of 257nm. Quantitative estimation of Paracetamol carried out by UV-Visible spectrophotometric methods, by using standard absorptivity value (assay method given in Indian Pharmacopoeia vol-II) Result: The percentage content sample was calculated by UV analysis methods using appropriate formulae and also determined whether or not they comply with standard specifications as per IP. The percentage content of paracetamol in different brands of paracetamol tablets was compared by IP Method.