Keap1-Nrf2/ARE signaling pathway- A promising therapeutic pathway for diseases: A Review

Authors

  • SHIBLANASRIN Department of Pharmacology, College of Pharmaceutical Sciences, Govt. Medical College, Pariyaram, Kannur, Kerala- 670503
  • VIVEK D. Department of Pharmacology, College of Pharmaceutical Sciences, Govt. Medical College, Pariyaram, Kannur, Kerala- 670503
  • SHAHIN MUHAMMED T K Department of Pharmacology, College of Pharmaceutical Sciences, Govt. Medical College, Pariyaram, Kannur, Kerala- 670503
  • MRIDULA K Department of Pharmacology, College of Pharmaceutical Sciences, Govt. Medical College, Pariyaram, Kannur, Kerala- 670503
  • NAYANTHARA K.B. Department of Pharmacology, College of Pharmaceutical Sciences, Govt. Medical College, Pariyaram, Kannur, Kerala- 670503

Keywords:

Nrf2, Keap 1, liver, arthritis, neurodegenerative disease.

Abstract

Oxidative stress is the major causes of development and progression of many diseases. Nrf2 is a transcriptional factor that regulates the stress response by binding with ARE in nucleus and causes induction of antioxidant genes and phase 2 detoxifying enzymes. In normal conditions Nrf2 inhibited by Keap 1 and during redox imbalance or oxidative stress, Nrf2 gets activated. During such
condition Nrf2 activity eventually gets increased and causes the expression of antioxidant genes like HO-1 (Heme oxygenase-1), NQO-1 (NADPH quinone oxidoreductase 1), glutathione peroxidase. Thus, Nrf2-ARE pathway plays important role in diseases like liver disorders, respiratory diseases, inflammatory diseases, neurodegenerative diseases etc.

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Published

2023-09-26

How to Cite

SHIBLANASRIN, VIVEK D., SHAHIN MUHAMMED T K, MRIDULA K, & NAYANTHARA K.B. (2023). Keap1-Nrf2/ARE signaling pathway- A promising therapeutic pathway for diseases: A Review. International Journal of Pharmacy Research & Technology (IJPRT), 14(1), 9–18. Retrieved from https://ijprt.org/index.php/pub/article/view/221

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Section

Review Article

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