Analgesic and Anti Inflammatory Activity of the Leaves of Caryota urens Linn.

Abstract

STRACT Caryota urens Linn (Palmae) commonly known as Sugar palm is used in traditional medicine to treat hemicrania and rheumatic swelling. Methanolic extract of plant leaves was used to perform analgesic and anti inflammatory activity. Analgesic study was performed by hot plate and tail flick method and anti-inflammatory effect analyzed by carrageenan induced paw edema. The methanol extract produced significant dose-dependent inhibition of carrageenan-induced rat paw edema. The extract also showed marked analgesic activity. In both the model of analgesic activity methanolic extract of Caryota urens at doses of 200 mg/kg and 400 mg/ kg significantly increase reaction time in rats when compared with control. The dose 400 mg/kg of Caryota urens was highly significant which is comparable with standard in both the studies.Phytochemical investigation of Caryota urens extracts shows presence of phytosterols, tepenoids, flavonoids , tannins and Phenolic compounds which has been responsible for analgesic and anti inflammatory activity.