Evaluating the Hypolipidemic and Hepatoprotective effects of Varying Doses of Gymnema sylvestre in dyslipidemia induced hepatic injury: Impact on Physiological Restoration"

Abstract

Background: Dyslipidemia and liver dysfunction are major contributors to metabolic disorders and cardiovascular risk. Herbal medicines such as Gymnema sylvestre have gained attention due to their traditional use and reported pharmacological activities, including lipid regulation and hepatoprotection. However, evidence regarding dose-dependent physiological restoration remains limited.

Objective: To evaluate the hypolipidemic and hepatoprotective effects of varying doses of Gymnema sylvestre and to assess their impact on physiological restoration.

Methodology: An experimental study was carried out using controlled groups receiving different doses of Gymnema sylvestre. Serum lipid profile parameters (total cholesterol, triglycerides, LDL, HDL) and liver function biomarkers (ALT, AST, ALP, bilirubin) were analyzed to determine dose-dependent effects and hepatic protection.

Results: Administration of Gymnema sylvestre resulted in significant, dose-dependent reductions in total cholesterol, triglycerides, and LDL levels, with a concomitant increase in HDL. Liver enzyme levels showed marked improvement, indicating reduced hepatic injury and restoration of normal liver function, particularly at higher doses.

Conclusion: The findings demonstrate that Gymnema sylvestre exerts significant hypolipidemic and hepatoprotective effects in a dose-dependent manner, supporting its therapeutic potential in the management of dyslipidemia and liver dysfunction.