Formulation Optimization And Evaluation Of Evaluation Of Transdermal Drug Delivery System Of Felodipine

Abstract

Felodipine, a BCS class II calcium channel blocker, is utilized in the administration of hypertension and angina pectoris. Because of the unfortunate dissolvability and low bioavailability of the medication, there is a need to plan an elective course to accomplish a consistent plasma convergence of felodipine for its greatest remedial utility and can be accomplished by transdermal route.In this review, framework type transdermal patches were arranged utilizing various blends of hydrophilic polymer, to be specific, polyvinylpyrrolidone (PVP) and hydrophobic polymer, in particular, ethyl cellulose (EC) by dissolvable dissipation procedure and were oppressed for characterization.The Fourier change infrared examinations affirmed the similarity among medication and polymers. The patches F1 to F7exhibited uniform weight going from 153.3mg to 242.6mg And thickness of F1 to F7 are going from 0.133 to 0.22mm. Among the different clusters, the consistency weight and thickness shows that the polymeric arrangement of the medication is all around scattered in the patches. Every one of the details (F1 to F7) showed genuinely uniform medication content going from 95.77% to 98.67% individually. it is obviously demonstrated that the Felodipine transdermal patches containing Eudragit RS 100 in the proportion of 1:2 (F6) was the best detailing among the pre-arranged patches.