Inflammatory Pathways in Periodontitis: Correlation of  Gingival Crevicular Fluid Biomarkers with Radiographic  Defect Measures and Clinical Response to Adjunctive Local  Doxycycline

Sadia Khalid, Mohsina Hamid, Adnan Riaz, Tariq Saeed Siddiqui, Faiqa Saleem, Usman Saeed

Inflammatory Pathways in Periodontitis: Correlation of Gingival Crevicular Fluid Biomarkers with Radiographic Defect Measures and Clinical Response to Adjunctive Local Doxycycline

Authors

Sadia Khalid, Mohsina Hamid, Adnan Riaz, Tariq Saeed Siddiqui, Faiqa Saleem, Usman Saeed

Keywords:

periodontitis; gingival crevicular fluid; IL-1β; MMP-8; PGE2; doxycycline; local drug delivery; cone-beam computed tomography

Abstract

Objective: To evaluate the association between inflammatory biomarkers in gingival crevicular fluidand radiographic periodontal defect measures, and to assess the adjunctive clinical effect of locally delivered doxycycline hyclate gel used with scaling and root planing in patients with periodontitis

References

1. Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Clin Periodontol. 2018;45(Suppl 20):S149-S161. doi:10.1111/jcpe.12945

Downloads

Published

2026-05-14

How to Cite

Sadia Khalid, Mohsina Hamid, Adnan Riaz, Tariq Saeed Siddiqui, Faiqa Saleem, Usman Saeed. (2026). Inflammatory Pathways in Periodontitis: Correlation of Gingival Crevicular Fluid Biomarkers with Radiographic Defect Measures and Clinical Response to Adjunctive Local Doxycycline. International Journal of Pharmacy Research & Technology (IJPRT), 16(1), 2513–2519. Retrieved from https://ijprt.org/index.php/pub/article/view/1907