To Compare Uterine Contractility, Haemodynamic Changes of Intravenous Infusion versus Bolus Dose of Oxytocin in Elective Caesarean Delivery: A Prospective, Randomised Study

Abstract

Background: Caesarean Delivery is the most commonly performed surgery in women all over the world. These patients are always at increased risk of uterine atony, obstetric haemorrhage, postpartum haemorrhage and its related morbidities. Postpartum haemorrhage (PPH) remains a significant cause of maternal mortality and morbidity. The main cause of postpartum haemorrhage is uterine atony. Among the various uterotonics, oxytocin stands out as the preferred option for preventing and managing postpartum uterine atony, and it is utilized globally either as a bolus or via continuous infusion.

Methods: Pregnant women posted for elective caesarean surgeries under subarachnoid block admitted in district hospital, the study design was prospective, Randomised, double blinded study.

Result: The mean age in Group I was 24.62 ± 3.91 years and 25.24 ± 4.15 years in Group B (p = 0.568). The mean weight was 75.45 ± 12.61 kg in Group I and 72.21 ± 12.20 kg in Group B (p = 0.259). The mean height was 162.39 ± 8.79 cm in Group I and 160.18 ± 7.24 cm in Group B (p = 0.235). The mean BMI was 28.58 ± 4.00 kg/m² in Group I and 28.10 ± 4.12 kg/m² in Group B (p = 0.608). None of the differences were statistically significant.

Conclusion: The study suggests that the Bolus group exhibited faster achievement of uterine contractility, requiring higher oxytocin doses, but also demonstrated notable cardiovascular changes, including increased heart rate and reduced blood pressure.