Association of Blood Culture Results with C - reactive protein, Procalcitonin, And Serum Lactate Levels in Patients with Suspected Sepsis: a Prospective Observational Study

Authors

  • Dr. Jagadish Patil Assistant Professor, Department of Orthopaedics, Faculty of Medical Sciences, Khaja Bandanawaz University, Gulbarga – 585104, Karnataka, India.
  • Dr. Natasha Vaidya Associate Professor, Department of Microbiology, Gulbarga Institute of Medical Sciences, Gulbarga, Karnataka, India.
  • Dr. Rashmi S Consultant, Ophthalmology, Shivsharan Clinic, Gulbarga, Karnataka, India.

Abstract

Background: Sepsis presents a critical diagnostic challenge where timely biomarker analysis is paramount before microbiological results become available.

Methods: A prospective observational study of 300 patients with suspected sepsis evaluated C-reactive protein (CRP), procalcitonin (PCT), and serum lactate alongside blood culture findings.

Results: Blood cultures were positive in 32.0% (n=96) of cases, predominantly Gram-negative pathogens (65.6%). PCT showed the strongest discriminatory ability for positive cultures (AUC 0.812), followed by serum lactate (AUC 0.724) and CRP (AUC 0.681).

Conclusion: Combined biomarker assessment, with particular reliance on PCT, offers strong complementary diagnostic power while blood cultures remain pending.

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Published

2025-12-29

How to Cite

Dr. Jagadish Patil, Dr. Natasha Vaidya, & Dr. Rashmi S. (2025). Association of Blood Culture Results with C - reactive protein, Procalcitonin, And Serum Lactate Levels in Patients with Suspected Sepsis: a Prospective Observational Study. International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 4960–4968. Retrieved from https://ijprt.org/index.php/pub/article/view/2752

Issue

Vol. 15 No. 2 (2025)

Section

Research Article

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Copyright (c) 2025 Authors

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