Opioid-Free Multimodal Analgesia versus Conventional Opioid-Based  Analgesia in Adults Undergoing Laparoscopic Cholecystectomy: A  Prospective Randomized Controlled Trial.

Rouhi Kauser, Borra Venkata Sai Santosh , Kiran Dyavanagoudar , Mirza Sanaulla

Opioid-Free Multimodal Analgesia versus Conventional Opioid-Based Analgesia in Adults Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial.

Authors

Rouhi Kauser, Borra Venkata Sai Santosh , Kiran Dyavanagoudar , Mirza Sanaulla

Keywords:

Opioid-free analgesia; anaesthesia; laparoscopic cholecystectomy; postoperative pain; rescue analgesia; postoperative nausea and vomiting; opioid-sparing analgesia.

Abstract

Background: Laparoscopiccholecystectomy is associated withpostoperative pain that may requiresystemic analgesia. Although opioidsprovide effective analgesia, their use isassociated with adverse effects such as nausea, vomiting, sedation, pruritus, andrespiratory depression. Multimodalanalgesia using non-opioid agents

References

1. Breazu C, Margarit S, Bartos A, Ionescu D. Postoperative analgesia after laparoscopic cholecystectomy—prospective, randomized, double blind, control trial. Chirurgia (Bucur). 2022;117(5):563-571

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Published

2025-07-15

How to Cite

Rouhi Kauser, Borra Venkata Sai Santosh , Kiran Dyavanagoudar , Mirza Sanaulla. (2025). Opioid-Free Multimodal Analgesia versus Conventional Opioid-Based Analgesia in Adults Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial . International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 4969–4983. Retrieved from https://ijprt.org/index.php/pub/article/view/2759