In Vitro Cytotoxicity of Methanolic Extract of Solanum nigrum Using MCF-7 Cell Line

Abstract

The discovery of the increased complexity of cancer has led us to consider it as a group of diverse diseases more than an etiopathology. Cancer can be treated by surgery, chemotherapy, radiation therapy, immunotherapy, monoclonal antibody therapy or other methods. Solanum nigrum strongly promote perspiration. Numerous types of bioactive compounds have been isolated from plant sources. Solanum nigrum can be poisonous and the juice or an ointment prepared from the solanum nigrum can be used for skin problems and tumors. Methanolic extract of the solanum nigrum was studied for its anticancer activity in the form of anti tumor activity against MCF-7 cell line and VERO Cell line (African green monkey kidney cell line). From this cytotoxicity screening data by MTT and SRB assay, IC50 value methanolic extract of solanum nigrum 148.70 and 279.00, so it demonstrate that Methanolic extract of Solanum Nigrum was potentially cytotoxic effective against MCF-7 cells.