Organ Transplantation: Current Challenges and EmergingInnovationsacross Preservation,Immunology and Xenotransplantation
Keywords:
Organ transplantation, machine perfusion, donation after circulatory death, xenotransplantation, donor-derived cell-free DNA, immune tolerance, ischemia-reperfusion injury, organ allocationAbstract
Background: Organ transplantation has evolved from a life-saving surgical intervention into amultidisciplinary field integrating immunology, bioengineering, and data science. Despite majoradvances in donor management, perioperative care, and immunosuppression, long-term outcomesremain constrained by a persistent global shortage of transplantable organs, ischemia-reperfusioninjury, chronic rejection, and the toxicity of lifelong immunosuppression.
References
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2. Oniscu GC, et al. Scientific advances in the assessment, modification, and generation of transplantable organs for patients with end-stage organ disease. Lancet. 2025. Doi:10.1016/S0140-6736(25)00195-3.
