Role of Doxycycline in Seropositive Paediatric Dengue and Its Effect on  Inflammatory Markers: A Prospective Randomized Case-Control Study

Dr sakalesh Hosamani, Dr Aishwarya Patil, Dr. Mahantesh Matti

Role of Doxycycline in Seropositive Paediatric Dengue and Its Effect on Inflammatory Markers: A Prospective Randomized Case-Control Study

Authors

Dr sakalesh Hosamani, Dr Aishwarya Patil, Dr. Mahantesh Matti

Keywords:

Paediatric dengue, seropositive dengue, Doxycycline, randomized controlled trial, inflammatory markers, cytokine-mediated inflammation, fever duration, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum ferritin, lactate dehydrogenase (LDH).

Abstract

Background: Dengue virus (DENV) infectionpresents a broad clinical spectrum ranging from self limiting febrile illness to severe dengue driven bysystemic immune activation and capillary leakage.Doxycycline possesses immunomodulatory andantiviral properties that may attenuate cytokinemediated inflammatory cascades.

References

1. World Health Organization. (2009). Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control (New ed.). World Health Organization.

2. Simmons, C. P., Farrar, J. J., Nguyen, v. V., & Wills, B. (2012). Dengue. The New England Journal of Medicine, 366(15), 1423–1432

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Published

2026-09-03

How to Cite

Dr sakalesh Hosamani, Dr Aishwarya Patil, Dr. Mahantesh Matti. (2026). Role of Doxycycline in Seropositive Paediatric Dengue and Its Effect on Inflammatory Markers: A Prospective Randomized Case-Control Study. International Journal of Pharmacy Research & Technology (IJPRT), 16(2), 4146–4149. Retrieved from https://ijprt.org/index.php/pub/article/view/2984