Predictive Role of Total Bilirubin, Alkaline Phosphatase, and Biliary  Microbiota in Detecting Extra-Hepatic Biliary Obstruction

Usama Yaseen, Haleema Rafique, Zahid Rashid, Muzamil Liaqat Ali, Sajjad Hussain Sabir, Mariya Ali, Jowayria Tayrab

Predictive Role of Total Bilirubin, Alkaline Phosphatase, and Biliary Microbiota in Detecting Extra-Hepatic Biliary Obstruction

Authors

Usama Yaseen, Haleema Rafique, Zahid Rashid, Muzamil Liaqat Ali, Sajjad Hussain Sabir, Mariya Ali, Jowayria Tayrab

Keywords:

extra-hepatic biliary obstruction; biliary microbiota; Enterobacteriaceae; total bilirubin; alkaline phosphatase

Abstract

Extra-hepatic biliary obstruction (EHBO) poses significant diagnostic uncertainty, particularlywhen radiologic imaging is equivocal. This prospective experimental study evaluates thepredictive power of serum total bilirubin (TBil), alkaline phosphatase (ALP), and biliary

References

Chen, Y., Li, X., Zhang, Z., & Zhao, Y. (2023). Microbial profiling of bile in patients with cholangiocarcinoma and benign biliary obstruction. Frontiers in Microbiology, 14, 1170894. https://doi.org/10.3389/fmicb.2023.1170894

Wang, L., Xu, J., Li, Q., & Sun, X. (2024). Comparative bile microbiota analysis in patients with benign and malignant biliary obstruction. International Journal of Molecular Sciences, 25(4), 1577. https://doi.org/10.3390/ijms25041577

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Published

2025-07-28

How to Cite

Usama Yaseen, Haleema Rafique, Zahid Rashid, Muzamil Liaqat Ali, Sajjad Hussain Sabir, Mariya Ali, Jowayria Tayrab. (2025). Predictive Role of Total Bilirubin, Alkaline Phosphatase, and Biliary Microbiota in Detecting Extra-Hepatic Biliary Obstruction . International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 844–850. Retrieved from https://ijprt.org/index.php/pub/article/view/788