Comparative Effectiveness of Ketamine Versus Electroconvulsive Therapy in  Treatment-Resistant Major Depressive Disorder

Jalaluddin Rumi, Junaid Rasool, Farooq Sultan Muhammad Usman, Bhawna Devi, Syed Ahmed Mahmud

Comparative Effectiveness of Ketamine Versus Electroconvulsive Therapy in Treatment-Resistant Major Depressive Disorder

Authors

Jalaluddin Rumi, Junaid Rasool, Farooq Sultan Muhammad Usman, Bhawna Devi, Syed Ahmed Mahmud

Keywords:

treatment-resistant depression; ketamine; electroconvulsive therapy; randomized controlled trial; cognitive outcomes

Abstract

This randomized, noninferiority trial evaluates the clinical efficacy, cognitive outcomes, andtolerability of intravenous ketamine versus electroconvulsive therapy (ECT) in 365 adults withnonpsychotic, treatment-resistant major depressive disorder

References

Andrade, C. (2021). Ketamine for treatment-resistant depression: Rapid antidepressant action and potential mechanisms. The Journal of Clinical Psychiatry, 82(1), 20f13841. https://doi.org/10.4088/JCP.20f13841

Bahji, A., & Vazquez, G. H. (2021). ECT versus ketamine for treatment-resistant depression: A systematic review and meta-analysis. Journal of Affective Disorders, 289, 308–314. https://doi.org/10.1016/j.jad.2021.05.054

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Published

2025-08-07

How to Cite

Jalaluddin Rumi, Junaid Rasool, Farooq Sultan Muhammad Usman, Bhawna Devi, Syed Ahmed Mahmud. (2025). Comparative Effectiveness of Ketamine Versus Electroconvulsive Therapy in Treatment-Resistant Major Depressive Disorder . International Journal of Pharmacy Research & Technology (IJPRT), 15(2), 1070–1076. Retrieved from https://ijprt.org/index.php/pub/article/view/847