Formulation, Characterization and In-vitro Evaluation of Aceclofenac Solid Dispersion in Corporated Gels

Abstract

Aceclofenac, an analgesic and anti inflammatory drug is used in treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Various batches of Aceclofenac solid dispersions were prepared by physical mixing, fusion and solvent evaporation methods using PVP as carrier to enhance the solubility of drug. The formulations evaluated for drug content, in-vitro dissolution study and also characterized by IR study. There is no interaction between drug and carrier. The general trend indicated that there was an increase in in-vitro drug release for solid dispersion prepared in PVP. Based on invtiro drug release pattern, 1:3 drug carrier ratio was selected as ideal dispersion for gels prepared by solvent evaporation technique. HPMC selected as ideal gel base for preparation of gels and dispersions are incorporated to gel bases by trituration. Formulations were characterized for rheological studies, drug content estimation and in-vitro diffusion study, IR spectroscopy. All these properties were found to be ideal. The in vitro release of Aceclofenac solid dispersion incorporated gel is significantly improved when compared to pure drug in corporated gel.