Glipizide Loaded Gastro Retentive Floating Tablets: Formulation and in vitro Evaluation

Abstract

The objective of this research was to formulate and evaluate hydro dynamically balanced controlled drug delivery system of Glipizide. Initially, considering buoyancy as the main criteria, blank tablets were compressed for different formulae with various polymers like Carbopol-940p, HPMC, Citric acid and sodium bi carbonate. The formula selected for design had a combination of Glipizide, Carbopol-940p, HPMC, Citric acid. The tablets were prepared by direct compression method and evaluated for Glipizide content, in vitro release profile and buoyancy. The dissolution study was carried out in simulated gastric fluid using USP dissolution test apparatus employing paddle stirrer. Duration of buoyancy was observed simultaneously when the dissolution has carried out. The Glipizide content of F9 batch 97.87±0.16% and in-vitro release was found to be in the range of 98.85% and from the above result it was concluded F9 was the optimized formulation. This indicates the suitability of the technique chosen for the present dosage form.