Formulation and Evaluation of Poorly Soluble Aceclofenac by Complexation With β-Cyclodextrin

Abstract

Aceclofenac is an effective analgesic and anti-inflammatory drug prescribed widely in various types of pain and inflammation. Aceclofenac is partially insoluble in water and aqueous fluid and as such it exhibits poor variable oral bioavailability. Aceclofenac needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. Among the various approaches to enhance the solubility and dissolution rate of poorly soluble drugs complexation with cyclodextrin is an effective and industrially accepted technique. In the present investigation, Complexation of aceclofenac with β-CD was carried out by using various techniques like kneading method, co-precipitate method & solvent evaporation method and compared with physical mixture method. From the various characterization studies like drug content, production yield & in vitro dissolution study, batch abc-3 by kneading method was selected as optimised batch. Optimised batch was also studied for FTIR and DSC.