Formulation and evaluation of osmotic tablets of Ranolazine
Keywords:Osmotic tablets, HPMC, Osmogen, Zero-order release system
Ranolazine is a clinically effective antianginal agent that has been used as the sodium- dependent calcium ion influx inhibitor and inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle. Osmotic tablets of ranolazine were prepared by using polymers like HPMC K4M, lactose, povidone K-30, carbopol. The effect of the storage at high temperatures at 40°C, 50°C and 60°C for a period of 3 months on the chemical stability of the selected tablets and prediction of the shelf life was also assessed. Nine formulations were formulated. Pre-compression parameters such as Angle of repose, bulk density, Carr’s index, Haunser ratio were evaluated. The purpose of this work was to formulate a solid dosage form for Ranolazine using the principles of osmosis which will bring down its dosing frequency to once a day and at the same time produce a zero-order release system.
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