Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib

Authors

  • RUPA RANI Department Of Pharmacy Kgr Institute Of Technology And Management Rampallyvill, Keesara Mdl, M.M Dist-5013, Ts
  • V. ANJANEYULU Department Of Pharmacy Kgr Institute Of Technology And Management Rampallyvill, Keesara Mdl, M.M Dist-5013, Ts
  • G.VIJAY KUMAR Department Of Pharmacy Kgr Institute Of Technology And Management Rampallyvill, Keesara Mdl, M.M Dist-5013, Ts

DOI:

https://doi.org/10.31838/ijprt/13.02.08

Keywords:

Colon drug delivery system, Targeted System, Enteric coated tablet, Time and pH dependent system

Abstract

In the present investigation, an attempt was made to formulate the time and pH dependent drug delivery system, reduce the frequency of dose administeration, and prevent ulcerative colitis by developing sustained delayed release tablets using a combination of Eudragit S-100 and L-100 as enteric coating. The core tablets of Celecoxib were prepared using the direct compresion method. The aim of the present study is to develop colon specific drug delivery of Celecoxib sustained release enteric coated tablet for ulcerative colitis using HPMC K-4M as a semisynthetic polymer. The impact of polymer concentration and superdisintegrant concentration was also studied. In-vitro drug release research was performed on the enteric coated Celecoxib tablet using simulated gastric fluid (0.1N HCl) for 2 hours, simulated intestinal fluid (pH 7.4) for 3 hours, and the simulated colonic fluid (pH 6.8) for 7 hours as a dissolution fluid. The study showed that the coating had a significant impact on the lag time before medication release. In the treatment of colonic illness and the oral administration of medications that are unstable and vulnerable to enzymatic degradation in the upper GI tract, colon drug delivery is advantageous. The results also showed that a mixture of Eudragit S-100 and L-100 may be used to coat tablets for medication delivery to the colon.

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Published

2023-03-21

How to Cite

RANI, R., ANJANEYULU, V., & KUMAR, G. (2023). Forulation And Evaluation of Colon Specific Drug Delivery System of Celecoxib. International Journal of Pharmacy Research & Technology (IJPRT), 13(2), 65–76. https://doi.org/10.31838/ijprt/13.02.08

Issue

Section

Research Article