Role of Vitamin D3 Supplementation in the Management of Chronic Rhinosinusitis without Nasal Polyposis: A Prospective Comparative Study
Keywords:
Chronic rhinosinusitis, Vitamin D3, SNOT-22, Lund–Mackay score, inflammation, supplementationAbstract
Background: Chronic rhinosinusitis (CRS) is a common inflammatory condition of the paranasal sinuses that significantly affects quality of life. Emerging evidence suggests a potential role of vitamin D in immune modulation and inflammation; however, its therapeutic role in CRS remains uncertain. Objective: To evaluate the effect of oral vitamin D3 supplementation on clinical symptoms and radiological
outcomes in patients with chronic rhinosinusitis without nasal polyposis (CRSsNP).
References
Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology Supplement. 2020;29:1–464.
Hastan D, Fokkens WJ, Bachert C, Newson RB, Bislimovska J, Bockelbrink A, et al. Chronic rhinosinusitis in Europe—an underestimated disease. Allergy. 2011;66(9):1216–23.
Bachert C, Zhang N. Chronic rhinosinusitis and asthma: novel understanding of the role of IgE ‘above atopy’. J Intern Med. 2012;272(2):133–43.
