Formulation And Invitro Evaluation Of Nlc Loaded (Transferosomal) Gel Drug Nabumetone

B.RAVINDRA BABU; V. SWAPNA; B.RASAGNA REDDY

doi:10.31838/ijprt/13.02.13

Formulation And Invitro Evaluation Of Nlc Loaded (Transferosomal) Gel Drug Nabumetone

Authors

B.RAVINDRA BABU Pulla Reddy Institute of Pharmacy, Department of Pharmaceutics, Domadugu,Gummadidala (M), Sangareddy district, Telangana, India.
V. SWAPNA Pulla Reddy Institute of Pharmacy, Department of Pharmaceutics, Domadugu,Gummadidala (M), Sangareddy district, Telangana, India.
B.RASAGNA REDDY Pulla Reddy Institute of Pharmacy, Department of Pharmaceutics, Domadugu,Gummadidala (M), Sangareddy district, Telangana, India.

DOI:

https://doi.org/10.31838/ijprt/13.02.13

Keywords:

NLC and SLN, Formulation, Evaluation, Invitro studies

Abstract

The present research work was designed to prepare Nabumetone -loaded nano lipid carriers (NLs) for ocular delivery. NLs were prepared by the emulsification–homogenization method and further optimized by the Box Behnken design. AM-NLs were optimized using the independent constraints of homogenization speed (A), surfactant concentration (B), and lipid concentration (C) to obtain optimal NLs (AM-NLop). The selected AMNLop was further converted into a sol-gel system using a mucoadhesive polymer blend of sodium alginate and hydroxyl propyl methyl cellulose (AM-NLopIG). The sol-gel system was further characterized for drug release, permeation, hydration, irritation, histopathology, and antibacterial activity.

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Published

2023-03-21

How to Cite

BABU, B., SWAPNA, V., & REDDY, B. (2023). Formulation And Invitro Evaluation Of Nlc Loaded (Transferosomal) Gel Drug Nabumetone. International Journal of Pharmacy Research & Technology (IJPRT), 13(2), 126–132. https://doi.org/10.31838/ijprt/13.02.13