Liquid Solid Compaction Technique : Advances The Stability, Dissolving Rate And Oral Bioavailability Of Poorly Soluble Drug – Pioglitazone

Abstract

The aim of present study is to enhance the dissolution of poorly water soluble drug of Pioglitazone HCl by liquisolid compact technique. Liquid solid compact were prepared using PEG-400 as non-volatile solvent, Microcrystalline cellulose as carrier and cross povidone as superdisintegrant.The compatibility of excipients and drug was confirmed by FT-IR studies. The dissolution studies for prepared liquid solid tablet were distinctly higher as compared to directly compressed tablets which show significance increased in wetting properties and surface area of drug available for dissolution. The optimized formulation of liquid solid pioglitazone tablet shows higher drug release when compared to marketed formulation. The mechanism of drug release studied for best formulations where fitted in accordance with higuchi model and korsemeyer peppas model it is evident that a linear relationship was obtained showing that is an apparent first order process.