Gut–Brain Axis Modulation of Acute Pain: A Systematic Review of  Experimental and Clinical Evidence

V. Sathyaprabu. Nevetha Priyadarshini, U. Shobi Priya, S Parthasarathy, P. Krubaa

Gut–Brain Axis Modulation of Acute Pain: A Systematic Review of Experimental and Clinical Evidence

Authors

V. Sathyaprabu. Nevetha Priyadarshini, U. Shobi Priya, S Parthasarathy, P. Krubaa

Keywords:

Gut–Brain Axis; Acute Pain; Gut Microbiota; Nociceptive Signalling; Vagus Nerve.

Abstract

Background: Acute pain is a protective physiological response to tissue injury that hastraditionally been explained by peripheral nociceptor activation and central nervous system processing. Emerging evidence suggests that the gut–brain axis, a bidirectional communicationnetwork linking the gastrointestinal tract

References

1. Mayer EA. Gut feelings: the emerging biology of gut–brain communication. Nat Rev Neurosci. 2011;12:453–466.

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Published

2026-06-25

How to Cite

V. Sathyaprabu. Nevetha Priyadarshini, U. Shobi Priya, S Parthasarathy, P. Krubaa. (2026). Gut–Brain Axis Modulation of Acute Pain: A Systematic Review of Experimental and Clinical Evidence . International Journal of Pharmacy Research & Technology (IJPRT), 16(1), 4559–4580. Retrieved from https://ijprt.org/index.php/pub/article/view/2177