Eccrine Syringofibroadenoma (Of Mascaro): A Rare Case Report

Abstract

Eccrine syringofibroadenoma is a very rare, benign, adnexal neoplasm derived from cells of the acrosyringium of eccrine sweat ducts and glands, with a propensity for extremities in elderly persons, especially palms and soles. It was first described by Mascaro in 1963. It has a variety of clinical manifestations and distribution of lesions, yet a characteristic histological appearance. In order to illustrate a typical presentation of the tumor, we report a case of eccrine syringofibroadenoma that occurred in a 69-year-old man. He presented to us with unilateral(right) distal lower limb lesions with marked trophic skin changes and extensive non-healing ulcerations associated with necrosis and erythematous nodular plaques, over a period of 1 year. Histopathological evaluation of skin biopsy from representative site revealed slender anastomosing network of monomorphous cuboidal cell cords extending from basal layer of epidermis infiltrating into dermis, with focal luminal differentiation resembling duct structures, embedded in a marked fibrovascular myxoid stroma, consistent with the diagnosis of eccrine syringofibroadenoma. Complete surgical excision is advised for these tumours in view of the risk of carcinomatous transformation.