HAEMODYNAMIC STABILITY AND ADVERSE EFFECTS OF INTRATHECAL NALBUPHINE VERSUS FENTANYL AS ADJUVANTS TO HYPERBARIC BUPIVACAINE IN LOWER LIMB SURGERY
Keywords:
nalbuphine; fentanyl; hyperbaric bupivacaine; spinal anaesthesia; haemodynamics; hypotension; bradycardia; adverse effects.Abstract
Background: Intrathecal opioids improve the quality and duration of spinal anaesthesia but may produce haemodynamic and opioid-related adverse effects. Nalbuphine has been proposed as an alternative to fentanyl because of its potentially favourable adverse-effect
profile. This study compared perioperative haemodynamic changes and adverse effects following intrathecal nalbuphine or fentanyl combined with hyperbaric bupivacaine.
References
1. Gupta K, Rastogi B, Gupta PK, et al. Intrathecal nalbuphine versus intrathecal fentanyl as adjuvant to 0.5% hyperbaric bupivacaine for orthopedic surgery of lower limbs under subarachnoid block. Indian J Pain. 2016;30:90-95.
2. Culebras X, Gaggero G, Zatloucal J, et al. Advantages of intrathecal nalbuphine compared with intrathecal morphine after caesarean delivery. AnesthAnalg. 2000;91:601-605.
