A STUDY OF THE ANTIINFLAMMATORY ACTIVITY OF STEM BARK OF RHAMNUS PURPUREUS

Abstract

The present study was facilitated to screen the anti-inflammatory effect of bark of the Rhamnus purpureus. Rhamnus purpureus commonly known as Gaunta a deciduous shrub found in the Himalayan range, Himachal Pradesh and Bhutan. In present study the stem bark of Rhamnus purpureus was chopped and extracted in ethanol butenol, chloroform and evaluated for carregenum, cotton pallet induced granulloma in Wister Albino Rats. The results revealed that crued ethonolic extract showed maximum inhibition in caragenum induced rat paw edema followed by ethanol, butenol, and chloroform extract. The ethonolic extract of infective dose 200mg/kg body weight showed significant anti inflammatory activity with inhibition of 41.05%, 49.35%, 54.30%, and 54.77%, and butanolic extract showed significant results viz. 46.01%, 49.80%, 49.17%, 50.28%. and the standard drugs indomethacin also compared (10mg/ kg) showed inhibition of 50.69%, 51.63%, 50.46%, 51.78% after 1,2,3,and 4 hours of treatment respectively. The result indicates that the ethonolic extract as well as butonilic extract revealed strong inflammatory activity while chloroform showed less effective in comparision with indomethicin. The order of inhibition of carregenum induced rat paw edema was found to be - indomethecine > ethanol > butonol>chloroform>. In conclusion to above study it has been seen that the Rhamnus purpureus was found to have great anti-inflammatory response and can be substitute or alternative for synthetic or chemically derived drugs.