Effect of Nitrous Oxide–Oxygen Mixture versus Oxygen Alone on Propofol  Induction Dose, Induction Time, and Haemodynamic Response to  Laryngoscopy: A Randomised, Single-Blinded Trial

Sainath, Diksha, Priyanka; Sainath, Diksha, Priyanka

Effect of Nitrous Oxide–Oxygen Mixture versus Oxygen Alone on Propofol Induction Dose, Induction Time, and Haemodynamic Response to Laryngoscopy: A Randomised, Single-Blinded Trial

Authors

Sainath, Diksha, Priyanka
Sainath, Diksha, Priyanka

Keywords:

Propofol; Nitrous oxide; Anaesthesia induction; Laryngoscopy; Haemodynamics; Oxygen saturation.

Abstract

Background and Aims: Propofol is awidely used induction agent but producesdose-related cardiovascular depression.Nitrous oxide (N₂O), through its analgesic and second-gas effects, may reduce propofolrequirements

References

1. Ng JM, Hwang NC. Inhaling nitrous oxide reduces the induction dose requirements of propofol. Anesth Analg 2000;90:1213–6.

2. Domínguez VC, Bellolio PC. Influence of inhaled nitrous oxide on the induction doses of propofol and thiopental assessed by auditory evoked potentials. Rev Esp Anestesiol Reanim 2007;54:475–9.

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Published

2026-07-07

How to Cite

Sainath, Diksha, Priyanka, & Sainath, Diksha, Priyanka. (2026). Effect of Nitrous Oxide–Oxygen Mixture versus Oxygen Alone on Propofol Induction Dose, Induction Time, and Haemodynamic Response to Laryngoscopy: A Randomised, Single-Blinded Trial . International Journal of Pharmacy Research & Technology (IJPRT), 16(2), 231–243. Retrieved from https://ijprt.org/index.php/pub/article/view/2276