Association of Twist expression with multilocular and unilocular variant of odontogenic keratocyst

Authors

  • Naveed Khan Demonstrator, Department of Oral Pathology, Ayub Medical College Abbottabad, Abbottabad, Pakistan.
  • Benish Aleem Assistant Professor, Institute of Pathology and Diagnostic Medicine, Khyber Medical University Peshawar, Peshawar, Pakistan.
  • Alishba Moeen Dental Assistant, Mississauga, Canada.
  • Ali Saad Tariq Assistant Professor, Department of Oral Biology, Islam Dental College, Sialkot. Pakistan,
  • Naveed A. Khawaja Associate Professor / HOD, Department of Oral & Maxillofacial Pathology, CIMS Dental College, National University of Medical Science, Multan, Pakistan.
  • Shahzad Ahmad Associate Professor, Department of Oral Pathology, MIMDC, Pakistan.
  • Hesham Rafiq Aziz Clinical Pathologist, Clinical Department, College of Medicine, Vision College, Riyadh, KSA.
  • Haider Ali Saleem Independent researcher. Clovis, California, USA.
  • Fatima Aleem MPhil Scholar, University of Health Sciences, Lahore, Pakistan.

Keywords:

Impacted tooth, Multilocular, Odontogenic keratocyst, Twist gene.

Abstract

Objective: To evaluate the association of twist expression with multilocular and unilocular variant of odontogenic keratocyst. Material &

Methods: This study was performed at the department of Pathology, Khyber Medical University Peshawar from January 2022 to June 2022. A total of 83 subjects meeting the inclusion criteria were included. According to WHO criteria, diagnosis of OKC was done. Twist immunoexpression of unilocular and multilocular OKC blocks were performed according to IHC protocol. The data were analysed using statistical software.

Results: Amongst the 43 cases of multilocular variant of odontogenic keratocyst, 41 (95.3%) were associated with the twist immuno-reactivity and 2 (4.75%) cases were negative, while amongst the 40 cases of unilocular variant of odontogenic keratocyst, 10 (25%) cases were associated with the twist immuno-reactivity and 30 (75%) cases were negative.

Conclusion: It is concluded that twist immunohistochemical expression was more common in the multilocular variant than unilocular variant. In multilocular variant of OKC, whether solitary or syndromic, its increased rate of recurrence and pathogenesis is greatly influenced by Twist expression and suggest its place in the neoplastic category.

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Published

2026-08-18

How to Cite

Naveed Khan, Benish Aleem, Alishba Moeen, Ali Saad Tariq, Naveed A. Khawaja, Shahzad Ahmad, Hesham Rafiq Aziz, Haider Ali Saleem, & Fatima Aleem. (2026). Association of Twist expression with multilocular and unilocular variant of odontogenic keratocyst. International Journal of Pharmacy Research & Technology (IJPRT), 16(2), 2989–2996. Retrieved from https://ijprt.org/index.php/pub/article/view/2801

Issue

Vol. 16 No. 2 (2026)

Section

Research Article

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