Clinical Outcomes of Percutaneous Coronary Intervention in Patients with Multivessel Coronary Artery Disease

Abstract

Introduction: Multivessel coronary artery disease involves significant stenoses in several epicardial vessels. It carries a substantial risk of ischemia and adverse events.

Objective: To evaluate clinical outcomes, procedural success, complications and short-term follow-up events in patients with multivessel coronary artery disease undergoing predominantly DES-based percutaneous coronary intervention (PCI).

Study Design: Prospective observational study.

Place and Duration of Study: Tertiary care hospitals of Khyber Pakhtunkhwa, from July, 2025 to December, 2025.

Methodology: A total of 120 consecutive adult patients with angiographically confirmed multivessel disease undergoing PCI were enrolled. Clinical, angiographic and procedural data were recorded on a structured proforma. In-hospital complications and short-term adverse cardiovascular events were assessed.

Results: The mean age was 59.4 ± 10.2 years, and 68.3% of patients were male. Hypertension (60.0%) and diabetes mellitus (45.0%) were the most common risk factors. Three-vessel disease was present in 36.7% of patients, with a mean of 2.2 ± 0.9 stents per patient. Procedural success was 95.0%. The most frequent in-hospital complications were arrhythmia (4.2%) and peri-procedural myocardial infarction (3.3%). In-hospital mortality was 1.7%. During follow-up, recurrent angina occurred in 11.7%, repeat revascularization in 5.0%, stent thrombosis in 0.8% and mortality in 1.7%.

Conclusion: DES-based PCI achieved high procedural success with low complication and short-term adverse event rates in multivessel coronary artery disease.