Comparison of Lipid Profile and Diabetic Peripheral Neuropathy among Patients Attending Chandka Teaching Hospital Larkana

Abstract

Background: Diabetic peripheral neuropathy (DPN) is one of the most common microvascular complications of diabetes mellitus and is frequently associated with dyslipidemia. Abnormal lipid profiles may contribute to the development and progression of neuropathic complications through vascular and metabolic mechanisms.

Objective: To compare serum lipid profile parameters between controlled and uncontrolled DPN patients.

Methodology: A comparative cross-sectional study was conducted among patients diagnosed with diabetic peripheral neuropathy. Serum lipid profile parameters were assessed and analyzed using descriptive statistics, including mean, median, mode, range, and standard deviation. The lipid profiles of controlled and uncontrolled DPN groups were compared.

Results: The mean triacylglycerol level was higher in the control DPN group (145 ± 47.9 g/dL) compared to the uncontrolled group (129 ± 44.67 g/dL). In contrast, total cholesterol was higher in the uncontrolled DPN group (244 ± 17.5 g/dL) than in the control group (224 ± 21.8 g/dL). Similarly, LDL levels were elevated in the uncontrolled group (126.6 ± 23 g/dL) compared with the control group (116.9 ± 21.2 g/dL). HDL levels were lower in the uncontrolled DPN group (37.1 ± 8.44 g/dL) than in the control group (39.9 ± 9.4 g/dL). These findings indicate a more adverse lipid profile among uncontrolled DPN patients, characterized by higher cholesterol and LDL levels and lower HDL concentrations.

Conclusion: Uncontrolled diabetic peripheral neuropathy was associated with unfavorable lipid profile changes, particularly elevated total cholesterol and LDL levels and reduced HDL concentrations. These findings suggest that dyslipidemia may play an important role in the progression and severity of diabetic peripheral neuropathy, emphasizing the need for effective lipid management as part of comprehensive diabetes care.