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Formulation and Evaluation of Nanoparticles containing Losartan Potassium

Amar Singh*, Amar Deep.

Cited by (1)

Abstract
Losartan potassium is an antihypertensive agent used in the treatment of hypertension which has low peak plasma concentration and half-life. It has been selected as candidate for the formulation of sustained release dosage forms. In the present work losartan potassium loaded chitosan nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions. Nanoparticles of different core: coat ratio were formulated and evaluated for drug content, loading efficiency, particles size, zeta potential, In vitro drug release and stability studies. Scanning Electron Microscopy indicated that the nanoparticles were found to be in nanometer range and showed ideal surface morphology. Differ ential scanning calorimetry analysis indicated that there were no chemical interactions between drug and polymer and stability of drug. In vitro release behavior from all the drug loaded batches were found to follow zero order and provided sustained release over a period of 24 hours. No appreciable difference was observed in the extent of degradation of product during 60 days in which nanoparticles were stored at various temperatures. The developed formulation overcomes and could possibility be advantageous in terms of sustained release dosage forms of losartan potassium.

Key words: Nanoparticles, Chitosan, Losartan potassium, Ionic gelation technique.


 
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This Article Cited By the following articles

Preparation and statistical optimization of Losartan Potassium loaded nanoparticles using Box Behnken factorial design: Microreactor precipitation
Chemical Engineering Research and Design 2015; 104(): 98-109.

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How to Cite this Article
Pubmed Style

Amar Singh , Amar Deep. Formulation and Evaluation of Nanoparticles containing Losartan Potassium. IJPRT. 2011; 1(1): 17-20. doi:10.31838/ijprt/01.01.04


Web Style

Amar Singh , Amar Deep. Formulation and Evaluation of Nanoparticles containing Losartan Potassium. https://www.ijprt.org/?mno=302643673 [Access: June 25, 2022]. doi:10.31838/ijprt/01.01.04


AMA (American Medical Association) Style

Amar Singh , Amar Deep. Formulation and Evaluation of Nanoparticles containing Losartan Potassium. IJPRT. 2011; 1(1): 17-20. doi:10.31838/ijprt/01.01.04



Vancouver/ICMJE Style

Amar Singh , Amar Deep. Formulation and Evaluation of Nanoparticles containing Losartan Potassium. IJPRT. (2011), [cited June 25, 2022]; 1(1): 17-20. doi:10.31838/ijprt/01.01.04



Harvard Style

Amar Singh , Amar Deep (2011) Formulation and Evaluation of Nanoparticles containing Losartan Potassium. IJPRT, 1 (1), 17-20. doi:10.31838/ijprt/01.01.04



Turabian Style

Amar Singh , Amar Deep. 2011. Formulation and Evaluation of Nanoparticles containing Losartan Potassium. International Journal of Pharmacy Research & Technology, 1 (1), 17-20. doi:10.31838/ijprt/01.01.04



Chicago Style

Amar Singh , Amar Deep. "Formulation and Evaluation of Nanoparticles containing Losartan Potassium." International Journal of Pharmacy Research & Technology 1 (2011), 17-20. doi:10.31838/ijprt/01.01.04



MLA (The Modern Language Association) Style

Amar Singh , Amar Deep. "Formulation and Evaluation of Nanoparticles containing Losartan Potassium." International Journal of Pharmacy Research & Technology 1.1 (2011), 17-20. Print. doi:10.31838/ijprt/01.01.04



APA (American Psychological Association) Style

Amar Singh , Amar Deep (2011) Formulation and Evaluation of Nanoparticles containing Losartan Potassium. International Journal of Pharmacy Research & Technology, 1 (1), 17-20. doi:10.31838/ijprt/01.01.04





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